Injectables
Polynucleotides (PDRN): Your Complete Guide
Polynucleotides — also known as PDRN — are one of the most exciting advances in aesthetic medicine. Unlike traditional fillers or skin boosters, polynucleotides work by stimulating your skin's own repair and regeneration processes at a cellular level. The result is genuine skin renewal: improved texture, reduced fine lines, brighter under-eyes, and a healthier, more youthful complexion.
What Are Polynucleotides?
Polynucleotides are long-chain DNA fragments derived from salmon or trout sperm (highly purified and biocompatible with human tissue). When injected into the skin, they activate fibroblast cells — the cells responsible for producing collagen and elastin — and promote tissue repair and regeneration. They also have anti-inflammatory properties and improve local blood circulation, contributing to a brighter, more even complexion.
What Areas Can Be Treated?
Polynucleotides are particularly effective for the under-eye area, where they reduce hollowness, dark circles, and fine lines. They can also be used across the full face, neck, décolletage, hands, and upper arms to improve skin quality, firmness, and hydration. A course of 2–3 treatments is typically recommended for optimal results.
What Results Can I Expect?
Results build gradually over 4–8 weeks as the skin's regenerative processes are activated. Clients typically notice improved skin texture and tone, reduced fine lines, brighter under-eyes, and a more rested, refreshed appearance. Results last approximately 6–12 months and can be maintained with periodic top-up treatments.
Is It Suitable for Me?
Polynucleotides are suitable for most adults looking to improve skin quality and address early to moderate signs of ageing. They are particularly popular with clients who want a natural, regenerative approach rather than volume-based treatments. They are not suitable during pregnancy or breastfeeding, or for those with fish allergies.
Common Questions
Frequently Asked Questions
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